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pentobarbital will lower the extent or influence of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.pentobarbital will reduce the extent or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducer